Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Building 2C, 8000, Aarhus, Denmark.
Cancer Causes Control. 2009 Nov;20(9):1587-92. doi: 10.1007/s10552-009-9403-2. Epub 2009 Jul 28.
To examine whether indicators of an increased prenatal estrogen exposure correlate with risk of testicular cancer.
This nationwide follow-up study was conducted by linking data on prenatal exposures obtained from medical and birth records for information on incident testicular cancer cases identified from the Danish Cancer Registry. The study population included all boys born between 1950 and 2002 and alive in April 1968 or later with restriction to sons of mothers born after 1935 and alive in April 1968.
A total of 2,151 incident testicular cancer cases were identified in 29 million person-years at risk. Men born with a high birth weight (>4,150 g) had an increased risk of testicular cancer [incidence rate ratio (IRR) = 1.6 (95% CI: 1.0, 2.4)]. Having a twin sister was associated with reduced risk [IRR = 0.5 (95% CI: 0.2, 1.1)], and the IRR for sons of mothers suffering from preeclampsia indicated a low risk [IRR = 0.6 (95% CI: 0.2, 2.0)], although none of these estimates were statistically significant. Increasing sib order and preterm birth was not associated with decreased risk.
Results provide no strong evidence for the hypothesis.
探讨产前雌激素暴露增加的指标是否与睾丸癌风险相关。
本全国性随访研究通过将从医疗和出生记录中获得的产前暴露数据与丹麦癌症登记处确定的睾丸癌病例信息相关联来进行。研究人群包括 1950 年至 2002 年之间出生且在 1968 年 4 月后存活，且其母亲出生于 1935 年后且在 1968 年 4 月后存活的所有男孩。
在 2900 万人年的风险期内共发现 2151 例睾丸癌新发病例。出生体重较高（>4150 克）的男性睾丸癌风险增加[发病率比（IRR）=1.6（95%CI：1.0，2.4）]。有双胞胎姐妹的男性睾丸癌风险降低[IRR=0.5（95%CI：0.2，1.1）]，母亲患有子痫前期的男性睾丸癌风险也较低[IRR=0.6（95%CI：0.2，2.0）]，尽管这些估计值均无统计学意义。增加同胞出生顺序和早产与风险降低无关。
结果并未为该假说提供有力证据。
