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母乳喂养能预防过敏性疾病吗?

[Does breast feeding protect from atopic diseases?].

作者信息

Haschke F, Pietschnig B, Böck A, Huemer C, Vanura H

机构信息

Universitäts-Kinderklinik Wien.

出版信息

Padiatr Padol. 1990;25(6):415-20.

PMID:2080064
Abstract

It is well established that food antigens can pass from mothers to infants via the breast milk. Bovine-beta-lactoglobulin has been detected in several breast milk samples from mothers with regular intake of cow's milk. Healthy breastfed infants can produce IgG antibodies against cow's milk protein and in infants at risk for atopic disease specific IgE antibodies were found before cow's milk based infant formula was introduced into the diet. However, several clinical studies in infants at risk for atopic disease indicate that exclusive breastfeeding decreases the incidence of atopic disease. The protective effect of breastfeeding is only relative and it is uncertain, how long protection lasts. Sensitization to food antigens may occur already in utero, because infants whose mothers avoid common allergenic foods during the whole pregnancy and then during the lactation period have a lower incidence of atopic eczema than infants whose mothers are on an unrestricted diet. Avoidance of common allergenic foods only during the last trimester of pregnancy had no effect, because the fetus is capable of forming IgE immune response.

摘要

众所周知,食物抗原可通过母乳从母亲传递给婴儿。在经常摄入牛奶的母亲的几份母乳样本中检测到了牛β-乳球蛋白。健康的母乳喂养婴儿能够产生针对牛奶蛋白的IgG抗体,并且在引入基于牛奶的婴儿配方奶粉之前,在有患特应性疾病风险的婴儿中发现了特异性IgE抗体。然而,针对有患特应性疾病风险的婴儿的多项临床研究表明,纯母乳喂养可降低特应性疾病的发病率。母乳喂养的保护作用只是相对的,而且保护能持续多久尚不确定。对食物抗原的致敏可能在子宫内就已发生,因为母亲在整个孕期及哺乳期都避免食用常见致敏食物的婴儿,其患特应性湿疹的发生率低于母亲饮食不受限制的婴儿。仅在妊娠晚期避免食用常见致敏食物没有效果,因为胎儿能够形成IgE免疫反应。

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