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母乳喂养在过敏和哮喘发展中的作用。

The role of breast-feeding in the development of allergies and asthma.

作者信息

Friedman Noah J, Zeiger Robert S

机构信息

Southern California Permanente Medical Group, 7060 Clairemont Mesa Boulevard, San Diego, CA 92111, USA.

出版信息

J Allergy Clin Immunol. 2005 Jun;115(6):1238-48. doi: 10.1016/j.jaci.2005.01.069.

Abstract

Breast-feeding is the preferred method of infant nutrition for numerous reasons. However, its role in the prevention of allergic disease remains controversial. Reasons for this controversy include methodological differences and flaws in the studies performed to date, the immunologic complexity of breast milk itself and, possibly, genetic differences among patients that would affect whether breast-feeding is protective against the development of allergies or is in fact sensitizing. The preponderance of evidence does suggest, however, that there would be much to lose by not recommending breast-feeding. In general, studies reveal that infants fed formulas of intact cow's milk or soy protein compared with breast milk have a higher incidence of atopic dermatitis and wheezing illnesses in early childhood. Consistent with these findings, exclusive breast-feeding should be encouraged for at least 4 to 6 months in infants at both high and low risk of atopy and irrespective of a history of maternal asthma.

摘要

母乳喂养是婴儿营养的首选方式,原因众多。然而,其在预防过敏性疾病中的作用仍存在争议。造成这种争议的原因包括方法学差异以及迄今所开展研究中的缺陷、母乳本身免疫的复杂性,还可能包括患者之间的基因差异,这些差异会影响母乳喂养对过敏发展是具有保护作用还是实际上会致敏。不过,大量证据确实表明,不推荐母乳喂养会带来诸多损失。总体而言,研究显示,与母乳喂养的婴儿相比,食用完整牛奶配方奶粉或大豆蛋白配方奶粉的婴儿在幼儿期患特应性皮炎和喘息性疾病的几率更高。与这些研究结果一致,无论婴儿患特应性疾病的风险高低,也无论其母亲有无哮喘病史,都应鼓励纯母乳喂养至少4至6个月。

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