College of Natural Sciences, UT Austin, TX 78712, USA.
Curr Opin Chem Biol. 2010 Dec;14(6):685-92. doi: 10.1016/j.cbpa.2010.07.022. Epub 2010 Aug 26.
Differential sensing is continuing to develop as an alternative to traditional, selective chemosensing techniques. This technique takes a cue from how the human senses of taste and smell operate in order to obtain qualitative and even quantitative data on single analytes and mixtures. Whereas classical chemosensing techniques inspired by the 'lock-and-key' approach depend on the development of a selective receptor for a target analyte, pattern-based sensing depends on the development of an array of cross-reactive receptors, which produce a collection of responses upon the array's interaction with a target analyte. This review focuses on an approach to differential sensing that diversifies synthetic receptors to be used in an array via appending combinatorial peptidic arms, metal ions, and indicators to a core binding unit.
差分感应作为传统选择性化学传感技术的替代方法正在不断发展。该技术借鉴了人类味觉和嗅觉感知的原理，以获取关于单一分析物和混合物的定性甚至定量数据。受“锁钥”方法启发的经典化学传感技术依赖于为目标分析物开发选择性受体，而基于模式的传感则依赖于开发一组交叉反应性受体，这些受体在与目标分析物相互作用时会产生一系列响应。本综述重点介绍了一种通过将组合肽臂、金属离子和指示剂附加到核心结合单元上来使合成受体多样化以用于阵列的差分传感方法。
