Department of Pathology, Case Western Reserve University, Cleveland 44106, USA.
J Neuroimmunol. 2011 Jan;230(1-2):183-7. doi: 10.1016/j.jneuroim.2010.07.022.
Toll-like receptor 4 (TLR4) is expressed on a number of cells including neurons in the brain. However, it has yet to be determined if TLR4 is expressed on photoreceptor cells in the retina. In this report, we examined primary photoreceptor cells and an established photoreceptor cell line (661W). We found that functional TLR4 is constitutively expressed on photoreceptor cells, and can be activated by LPS. We conclude that TLR4 on photoreceptor cells could directly contribute to retinal inflammatory diseases and photoreceptor cell survival.
Toll 样受体 4（TLR4）表达于多种细胞，包括脑内神经元。然而，TLR4 是否表达于视网膜感光细胞尚未确定。在本报告中，我们检测了原代感光细胞和一个已建立的感光细胞系（661W）。我们发现功能性 TLR4 持续表达于感光细胞，且可被 LPS 激活。我们的结论是，感光细胞上的 TLR4 可能直接导致视网膜炎症性疾病和感光细胞存活受损。
