Department of Computer-Aided Molecular Design, Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
J Pharm Biomed Anal. 2011 Jan 5;54(1):222-4. doi: 10.1016/j.jpba.2010.07.039. Epub 2010 Aug 6.
The thermodynamic aspects of solubility process of sulfonamides with the general structures C(6)H(5)-SO(2)NH-C(6)H(4)-R (R=4-NO(2); 4-Cl) and 4-NH(2)-C(6)H(4)-SO(2)NH-C(6)H(4)-R (R=4-NO(2); 4-CN; 4-Cl; 4-OMe; 4-C(2)H(5)) in water, phosphate buffer with pH 7.4 and n-octanol (as phases modeling various drug delivery pathways) were studied using the isothermal saturated method.
使用等温饱和法研究了具有通式 C(6)H(5)-SO(2)NH-C(6)H(4)-R（R=4-NO(2); 4-Cl）和 4-NH(2)-C(6)H(4)-SO(2)NH-C(6)H(4)-R（R=4-NO(2); 4-CN; 4-Cl; 4-OMe; 4-C(2)H(5)）的磺胺类药物在水、pH 值为 7.4 的磷酸盐缓冲液和正辛醇（作为模拟各种药物输送途径的相）中的溶解过程的热力学方面。
