Bateman S T, Lichtman A H, Cramer C P
Department of Psychology, Dartmouth College, Hanover, NH 03755.
Pharmacol Biochem Behav. 1990 Oct;37(2):219-25. doi: 10.1016/0091-3057(90)90324-b.
Systemically administered serotonin, which does not pass the blood-brain barrier, inhibited nipple attachment behavior in 20- and 30-day-old rat pups. Xylamidine, a peripheral serotonin antagonist, attenuated the effects of serotonin, quipazine, and fenfluramine on nipple attachment behavior. Thus, serotonin receptors in the periphery may play an important role in the serotonergic inhibitory mechanism that has been hypothesized as the developing system leading to weaning. However, unlike more general 5-HT antagonists, xylamidine given alone failed to facilitate suckling, suggesting different sites of action for facilitation and inhibition of this infantile behavior.
系统给予的血清素不能透过血脑屏障，它抑制了20日龄和30日龄大鼠幼崽的乳头附着行为。外周血清素拮抗剂赛拉米定减弱了血清素、喹哌嗪和芬氟拉明对乳头附着行为的影响。因此，外周的血清素受体可能在被假设为导致断奶的发育系统的血清素能抑制机制中发挥重要作用。然而，与更一般的5-羟色胺拮抗剂不同，单独给予赛拉米定并不能促进哺乳，这表明促进和抑制这种婴儿行为的作用位点不同。
