Department of Pulmonary Diseases, Canisius-Wilhelmina Hospital, Weg door Jonkerbos 100, 6525 SZ Nijmegen, The Netherlands.
QJM. 2010 Dec;103(12):953-8. doi: 10.1093/qjmed/hcq144. Epub 2010 Aug 27.
Q fever is a zoonosis caused by the obligate intracellular bacterium Coxiella burnetii. The two long-term complications, after primary infection, are chronic Q fever in ∼1% of patients, and a chronic fatigue syndrome in 10-20%. However, the existence of a protracted decreased health status after Q fever remains controversial.
To determine the health status of the patients of the Q fever outbreak in The Netherlands in 2007, 1 year after primary infection.
Cross-sectional case-control study.
Health status of the patients from the 2007 Dutch Q fever outbreak was compared to age-, sex- and geographically matched and Q fever seronegative controls. Health status of both patients and controls was assessed with the Nijmegen Clinical Screening Instrument (NCSI).
Fifty-four Q fever patients provided 34 years of age- and sex-matched controls from the same neighbourhood. Eleven controls had positive Q fever serology and were excluded. Q fever patients had significantly more problems on the subdomains of symptoms and functional impairment. Overall quality of life was decreased in both patients and controls, 59% vs. 39%, respectively, ns). Severe fatigue levels were present in 52% of patients vs. 26% in controls (P < 0.05).
These data support a sustained decrease in many aspects of health status in Q fever patients in The Netherlands, 1 year after primary infection.
Q 热是一种由严格细胞内细菌贝氏柯克斯体引起的动物源性传染病。原发性感染后，有两种长期并发症，约 1%的患者发生慢性 Q 热，10-20%的患者发生慢性疲劳综合征。然而，Q 热后持续存在健康状况下降的情况仍存在争议。
确定 2007 年荷兰 Q 热爆发后患者的健康状况，即原发性感染后 1 年。
横断面病例对照研究。
将 2007 年荷兰 Q 热爆发患者的健康状况与年龄、性别和地理位置匹配且 Q 热血清阴性的对照进行比较。使用奈梅亨临床筛选工具（NCSI）评估患者和对照的健康状况。
54 例 Q 热患者提供了 34 名年龄和性别匹配的来自同一社区的对照。11 名对照的 Q 热血清学呈阳性，被排除在外。Q 热患者在症状和功能障碍等子领域存在明显更多的问题。患者和对照的总体生活质量均下降，分别为 59%和 39%（均无统计学意义）。52%的患者存在严重疲劳，而对照组为 26%（P<0.05）。
这些数据支持荷兰 Q 热患者在原发性感染后 1 年，其健康状况的许多方面持续下降。
