Morroy Gabriella, Keijmel Stephan P, Delsing Corine E, Bleijenberg Gijs, Langendam Miranda, Timen Aura, Bleeker-Rovers Chantal P
Department of Infectious Diseases, Municipal Health Service Hart voor Brabant, 's-Hertogenbosch, the Netherlands.
Radboud Expertise Centre for Q fever, Department of Internal Medicine, Division of Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands.
PLoS One. 2016 May 25;11(5):e0155884. doi: 10.1371/journal.pone.0155884. eCollection 2016.
Long-term fatigue with detrimental effects on daily functioning often occurs following acute Q-fever. Following the 2007-2010 Q-fever outbreak in the Netherlands with over 4000 notified cases, the emphasis on long-term consequences of Q-fever increased. The aim of this study was to provide an overview of all relevant available literature, and to identify knowledge gaps regarding the definition, diagnosis, background, description, aetiology, prevention, therapy, and prognosis, of fatigue following acute Q-fever.
A systematic review was conducted through searching Pubmed, Embase, and PsycInfo for relevant literature up to 26th May 2015. References of included articles were hand searched for additional documents, and included articles were quality assessed.
Fifty-seven articles were included and four documents classified as grey literature. The quality of most studies was low. The studies suggest that although most patients recover from fatigue within 6-12 months after acute Q-fever, approximately 20% remain chronically fatigued. Several names are used indicating fatigue following acute Q-fever, of which Q-fever fatigue syndrome (QFS) is most customary. Although QFS is described to occur frequently in many countries, a uniform definition is lacking. The studies report major health and work-related consequences, and is frequently accompanied by nonspecific complaints. There is no consensus with regard to aetiology, prevention, treatment, and prognosis.
Long-term fatigue following acute Q-fever, generally referred to as QFS, has major health-related consequences. However, information on aetiology, prevention, treatment, and prognosis of QFS is underrepresented in the international literature. In order to facilitate comparison of findings, and as platform for future studies, a uniform definition and diagnostic work-up and uniform measurement tools for QFS are proposed.
急性Q热后常出现长期疲劳，对日常功能产生不利影响。在2007 - 2010年荷兰Q热爆发且报告病例超过4000例之后，对Q热长期后果的关注有所增加。本研究的目的是概述所有相关的现有文献，并确定关于急性Q热后疲劳的定义、诊断、背景、描述、病因、预防、治疗和预后方面的知识空白。
通过检索Pubmed、Embase和PsycInfo数据库，对截至2015年5月26日的相关文献进行系统综述。对纳入文章的参考文献进行手工检索以查找其他文献，并对纳入文章进行质量评估。
纳入57篇文章，4篇文献归类为灰色文献。大多数研究质量较低。研究表明，虽然大多数患者在急性Q热后6 - 12个月内从疲劳中恢复，但约20%的患者仍长期疲劳。有几个名称用于表示急性Q热后的疲劳，其中Q热疲劳综合征（QFS）最为常用。虽然QFS在许多国家被描述为经常发生，但缺乏统一的定义。研究报告了其对健康和工作的主要影响，并且常伴有非特异性症状。在病因、预防、治疗和预后方面没有共识。
急性Q热后的长期疲劳，通常称为QFS，对健康有重大影响。然而，关于QFS的病因、预防、治疗和预后的信息在国际文献中较少。为便于研究结果的比较，并作为未来研究的平台，提出了QFS的统一定义、诊断检查和统一测量工具。
