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来自嗜热古菌 Pyrococcus furiosus 的元素硫响应蛋白(SipA)受硫化物的调节,这种调节方式依赖于铁。

The elemental sulfur-responsive protein (SipA) from the hyperthermophilic archaeon Pyrococcus furiosus is regulated by sulfide in an iron-dependent manner.

机构信息

Department of Biochemistry and Molecular Biology, Life Sciences Bldg., University of Georgia, Athens, GA 30602-7229, USA.

出版信息

J Bacteriol. 2010 Nov;192(21):5841-3. doi: 10.1128/JB.00660-10. Epub 2010 Aug 27.

Abstract

The gene (sipA) encoding the sulfur-induced protein A (PF2025) is highly upregulated during growth of Pyrococcus furiosus on elemental sulfur (S(0)). Expression of sipA is regulated by sulfide, the product of S(0) reduction, but in an iron-dependent manner. SipA is proposed to play a role in intracellular iron sulfide detoxification.

摘要

编码硫诱导蛋白 A (PF2025) 的基因 (sipA) 在 Pyrococcus furiosus 以元素硫 (S(0)) 生长时高度上调。sipA 的表达受 S(0)还原产物硫化物的调节,但以铁依赖的方式进行。SipA 被提议在细胞内铁硫化物解毒中发挥作用。

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