Zyss Tomasz, Zieba Andrzej, Hese Robert T, Dudek Dominika, Grabski Bartosz, Gorczyca Piotr, Modrzejewska Renata
Department of Adult Psychiatry, University Hospital, Medical School of Jagellonian University, Cracow, Poland.
Neuro Endocrinol Lett. 2010;31(4):425-37.
Since 1999, attempts have been made in the application of a new technique called magnetic seizure therapy (MST) or magnetic convulsion therapy (MCT) in the treatment of depressive disorder--as an alternative to electroconvulsive treatment. The technique of rapid rate transcranial magnetic stimulation (rTMS) is used to evoke intentional and repeated magnetoconvulsive seizures, though it requires the use of stimulation parameters practically inaccessible in commercially available rTMS magnetic stimulators. Magnetic convulsion therapy has been tested on monkeys as well as humans. A decisive majority of studies carried out both on animals and humans addressed the issue of safety of the MST method and confirmed that the side-effects (mostly of a cognitive nature) which occurred after magnetic seizures were weaker than those observed after electroconvulsive seizures. An analysis of available sources, however, does not confirm any proven antidepressant action of the MST technique. No experimental investigations have been carried out on animal models of depression. Clinical effectiveness had been confirmed in merely a few (perhaps three) patients with depression. The authors submit the results of the hitherto conducted studies on MST to critical analysis, particularly in the aspect of their antidepressant efficacy.
自1999年以来，人们尝试应用一种名为磁休克疗法（MST）或磁惊厥疗法（MCT）的新技术来治疗抑郁症，作为电休克治疗的替代方法。快速重复经颅磁刺激（rTMS）技术用于诱发有意且重复的磁惊厥发作，不过这需要使用市售rTMS磁刺激器几乎无法达到的刺激参数。磁惊厥疗法已在猴子和人类身上进行了测试。在动物和人类身上进行的绝大多数研究都涉及MST方法的安全性问题，并证实磁惊厥发作后出现的副作用（大多是认知方面的）比电惊厥发作后观察到的副作用要轻。然而，对现有资料的分析并未证实MST技术有任何已被证实的抗抑郁作用。尚未在抑郁症动物模型上进行实验研究。仅在少数（可能三例）抑郁症患者中证实了临床有效性。作者对迄今为止进行的关于MST的研究结果进行批判性分析，特别是在其抗抑郁疗效方面。
