Arizona Research Laboratories, Division of Biotechnology, University of Arizona, Tucson, Arizona, USA.
Nat Genet. 2010 Oct;42(10):830-1. doi: 10.1038/ng.651. Epub 2010 Aug 29.
The ratio of X-linked to autosomal diversity was estimated from an analysis of six human genome sequences and found to deviate from the expected value of 0.75. However, the direction of this deviation depends on whether a particular sequence is close to or far from the nearest gene. This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males.
从对 6 个人类基因组序列的分析中估计了 X 连锁与常染色体多样性的比例，发现其偏离了 0.75 的预期值。然而，这种偏差的方向取决于特定序列是靠近还是远离最近的基因。这种模式可以用 X 连锁基因比常染色体基因受到更强的局部作用选择来解释，同时女性的有效种群大小大于男性。
