Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Nat Immunol. 2010 Oct;11(10):962-8. doi: 10.1038/ni.1929. Epub 2010 Aug 29.
Induced regulatory T cells (iT(reg) cells) can be generated by peripheral dendritic cells (DCs) that mediate T cell unresponsiveness to rechallenge with antigen. The molecular factors required for the function of such iT(reg) cells remain unknown. We report a critical role for the transcription cofactor homeodomain-only protein (Hop; also known as Hopx) in iT(reg) cells to mediate T cell unresponsiveness in vivo. Hopx-sufficient iT(reg) cells downregulated expression of the transcription factor AP-1 complex and suppressed other T cells. In the absence of Hopx, iT(reg) cells had high expression of the AP-1 complex, proliferated and failed to mediate T cell unresponsiveness to rechallenge with antigen. Thus, Hopx is required for the function of T(reg) cells induced by DCs and the promotion of DC-mediated T cell unresponsiveness in vivo.
诱导性调节 T 细胞（iTreg 细胞）可以由外周树突状细胞（DCs）产生，这些细胞介导 T 细胞对再次抗原刺激的无反应性。用于此类 iTreg 细胞功能的分子因素尚不清楚。我们报告了转录共因子同源域仅蛋白（Hop；也称为 Hopx）在 iTreg 细胞中的关键作用，以介导体内 T 细胞无反应性。Hopx 充足的 iTreg 细胞下调了转录因子 AP-1 复合物的表达，并抑制了其他 T 细胞。在没有 Hopx 的情况下，iTreg 细胞中 AP-1 复合物表达水平高，增殖并不能介导 T 细胞对再次抗原刺激的无反应性。因此，Hopx 是 DC 诱导的 T 细胞（Treg 细胞）功能所必需的，并且促进了体内 DC 介导的 T 细胞无反应性。
