调节性T细胞分化与功能的分子调控
Molecular orchestration of differentiation and function of regulatory T cells.
作者信息
Lu Li-Fan, Rudensky Alexander
机构信息
Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
出版信息
Genes Dev. 2009 Jun 1;23(11):1270-82. doi: 10.1101/gad.1791009.
Abstract
During the last decade, a unique mechanism of negative regulation of immune responses and inflammation by a dedicated population of so-called regulatory T cells (Treg) has become a focus of intensive investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of differentiation and function of Treg cells, the complex biology of these cells, including maintenance of immunological tolerance to "self" and regulation of immune responses to pathogens, commensals, and tumors, has become amenable to mechanistic studies. In this review, we discuss the molecular aspects of Treg cell lineage commitment, maintenance, and function.
摘要
在过去十年中，一类所谓的调节性T细胞（Treg）通过一种独特机制对免疫反应和炎症进行负调控，这已成为深入研究的焦点。通过发现转录因子Foxp3是Treg细胞分化和功能的核心分子决定因素，这些细胞的复杂生物学特性，包括对“自身”的免疫耐受维持以及对病原体、共生菌和肿瘤的免疫反应调节，已便于进行机制研究。在本综述中，我们讨论了Treg细胞谱系定向、维持和功能的分子层面。
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