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[细胞学中的转折点]

[Turning points in cytology].

作者信息

Scharf J H

机构信息

Institut für Anatomie der Martin-Luther-Universität Halle-Wittenberg.

出版信息

Acta Histochem Suppl. 1990;39:11-47.

PMID:2080255
Abstract

There is given a concise and woodcut-like survey over the history of cytology with was born by the pioneering of Hooke, Grew, Malpighi, and van Leeuwenhoek at the end of XVIIth century and three crises of this science. The first crisis of cytology resulted from barren discussions of the so-called preformation hypothesis and the monadism of Leibniz. These philosophical speculations caused a melting away of the concrete facts during the XVIIth century. After the rebuilding of cytology by Meyen and Brown during the XIXth century's early thirties and the propounding of the early cell-theory by Schleiden and Schwann, the second crisis was provoked since Schleiden and Schwann, clearer than Meyen, kept the hypothesis of equivocal or spontaneous generation that was alive since Aristotéles. This 2nd crisis showed a belated sequel in the middle of XXth century brought about by sloppy investigations of Lepesinskaja. The third crisis concerns the question whether there is or whether there is not existent a membran enveloping every animal cell. Whereas Schwann himself presupposed the cell membran as an integral part of each cell, Max Schultze negates its existence. After the creation of the membran theory of synapse by Sherrington, the neuron theory by Ramón y Cajal, and the membran theory of narcosis by Meyer and Overton, the negation of the cell membran was being combined successively with the neovitalistic hypothesis of neuronal networks of Bethe and others. This spectre could really wiped out not before the modern histochemistry and electron microscopy were established in the fifties of our century.

摘要

本文简要且如木刻般地概述了细胞学的历史,它始于17世纪末胡克、格鲁、马尔皮基和范·列文虎克的开创性工作以及该学科的三次危机。细胞学的第一次危机源于对所谓预成论假说和莱布尼茨单子论的空洞讨论。这些哲学思辨导致17世纪具体事实的消解。在19世纪30年代初迈恩和布朗对细胞学进行重建以及施莱登和施旺提出早期细胞理论之后,由于施莱登和施旺(比迈恩更明确地)秉持自亚里士多德时代就存在的无生源或自然发生假说,引发了第二次危机。20世纪中叶,列佩辛斯卡娅草率的研究带来了这次危机的滞后后果。第三次危机涉及是否存在包围每个动物细胞的膜这一问题。施旺本人预设细胞膜是每个细胞的组成部分,而马克斯·舒尔茨则否定其存在。在谢灵顿提出突触膜理论、拉蒙·伊·卡哈尔提出神经元理论以及迈耶和奥弗顿提出麻醉膜理论之后,对细胞膜的否定相继与贝西等人关于神经网络的新活力论假说结合在一起。直到20世纪50年代现代组织化学和电子显微镜技术建立之后,这个幽灵才真正被消除。

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