Department of Food & Nutrition, Bucheon University, Bucheon, South Korea.
Int J Vitam Nutr Res. 2010 Apr;80(2):87-96. doi: 10.1024/0300-9831/a000009.
The purpose of this study was to investigate whether the genetic polymorphisms of the uncoupling protein 1 (UCP1) and beta 3 adrenergic receptor (beta3-AR) were associated with differences in weight loss and lipid profiles in obese premenopausal women exposed to low-calorie meal replacements over a period of six weeks. Forty women between the ages of 20 and 35 were randomly divided into two groups, each of which consumed one of two low-calorie meal replacements containing either white rice or mixed rice. Although body weight, body mass index (BMI), blood glucose concentration, triglycerides, total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) were not significantly different by the UCP1 genotype in the white rice group, there were significant differences in body weight (p = 0.041), BMI (p = 0.027), and blood glucose concentration (p = 0.047) between carriers and non-carriers of the G allele in the mixed rice group after the six-week meal replacement intervention. The beta3-AR polymorphism showed no apparent affect on these parameters. Dietary fiber affects weight gain since it is closely related with absorption of nutrients. As a result, the AA type UCP1 genotype produced significant weight loss in the mixed rice group, but not in the white rice group.
本研究旨在探讨解偶联蛋白 1（UCP1）和β3 肾上腺素能受体（β3-AR）的基因多态性是否与肥胖绝经前妇女在接受低热量代餐 6 周期间体重减轻和血脂谱的差异有关。将 40 名年龄在 20 岁至 35 岁之间的女性随机分为两组，每组分别食用两种低热量代餐中的一种，其中含有白米或混合米。虽然白米组 UCP1 基因型的体重、体重指数（BMI）、血糖浓度、甘油三酯、总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）没有明显差异，但在混合米组，携带和不携带 G 等位基因的个体在 6 周的代餐干预后，体重（p=0.041）、BMI（p=0.027）和血糖浓度（p=0.047）有显著差异。β3-AR 多态性对这些参数没有明显影响。膳食纤维影响体重增加，因为它与营养物质的吸收密切相关。因此，UCP1 基因型 AA 型在混合米组产生显著的体重减轻，但在白米组没有。
