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一种用于改善钛骨整合的新型仿生治疗方法。

A novel biomimetic treatment for an improved osteointegration of titanium.

作者信息

Sandrini E, Chiesa R, Rondelli G, Santin M, Cigada A

机构信息

Department of Chemistry, Materials and Chemical Engineering ""G.Natta"", Politecnico di Milano, Milano - Italy.

出版信息

J Appl Biomater Biomech. 2003 Jan-Apr;1(1):33-42.

Abstract

Direct osteointegration of titanium and titanium alloys implants is one of the main goals of biomaterials research for dental and orthopedic applications. Chemical, mechanical or biological treatments are investigated searching for fast and durable implant to bone bonding. The aim of the present work is to assess the in vitro mineralisation capabilities and to investigate the mechanical and physico-chemical properties of a new biomimetic treatment on titanium. The new surface treatment was obtained using Anodic Spark Deposition technique, and consists of a first ASD treatment performed in solutions containing phosphate ions followed by a second ASD treatment in a solution rich in calcium ions. The resulting surface is finally treated by alkali etching. The physio-chemical and mechanical properties of this material are analyzed and the mineralization potential is considered by surface analysis after soaking it in different solutions of simulated body fluid (SBF). The developed biomimetic treatment was then compared to other treatments from the literature. The proposed treatment was found to possess a very high mineralization capaci-ty, that makes its application very interesting in terms of speed and strength of direct implant osteointegration. (Journal of Ap-plied Biomaterials & Biomechanics 2003; 1: 33-42).

摘要

钛及钛合金种植体的直接骨整合是牙科和骨科应用生物材料研究的主要目标之一。人们正在研究化学、机械或生物处理方法,以寻求快速且持久的种植体与骨的结合。本研究的目的是评估一种新型仿生处理钛的体外矿化能力,并研究其力学和物理化学性质。这种新型表面处理采用阳极火花沉积技术,包括在含磷酸根离子的溶液中进行第一次阳极火花沉积处理,随后在富含钙离子的溶液中进行第二次阳极火花沉积处理。最终对所得表面进行碱蚀刻处理。分析该材料的物理化学和力学性质,并通过将其浸泡在不同的模拟体液(SBF)溶液中后进行表面分析来评估其矿化潜力。然后将所开发的仿生处理与文献中的其他处理方法进行比较。结果发现,所提出的处理方法具有非常高的矿化能力,这使得其在直接种植体骨整合的速度和强度方面的应用非常有吸引力。(《应用生物材料与生物力学杂志》2003年;1:33 - 42)

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