Tamilselvi S, Raghavendran H Balaji, Srinivasan P, Rajendran N
Department of Chemistry, MIT Campus, Anna University, Chennai-44, India.
J Biomed Mater Res A. 2009 Aug;90(2):380-6. doi: 10.1002/jbm.a.32099.
In vitro studies of Ti-6Al-7Nb and Ti-5Al-2Nb-1Ta alloys were carried out by treating the specimens with 10 M NaOH at 60 degrees C for 24 h and subsequently heat-treated at 600 degrees C for 1 h. After the alkali and heat treatments, and on subsequent soaking in simulated body fluid (SBF), the morphological and compositional changes on the surface of the specimens were examined using scanning electron microscope attached with an energy-dispersive electron probe X-ray analyzer. The results revealed a dense and uniform bonelike apatite layer on the surface of treated substrates immersed in SBF solution. In vivo studies were carried out in rats to evaluate osteoconduction of Ti-6Al-7Nb and Ti-5Al-2Nb-1Ta alloys surface after alkali and heat treatments compared with untreated titanium alloys as the control. The following titanium implants were prepared from these species: (1) control without implant; (2) untreated titanium implant; (3) alkali- and heat-treated implant--the implants were immersed in 10 M NaOH solution at 60 degrees C for 24 h and subsequently heated at 600 degrees C for 1 h. The specimens were inserted into the medial side of each tibia of rats. Histologically, direct bone contact with the implant surface was significantly higher in the alkali heat-treated implants than the untreated titanium implants.
对Ti-6Al-7Nb和Ti-5Al-2Nb-1Ta合金进行了体外研究，方法是将试样在60℃下用10M的NaOH处理24小时，随后在600℃下进行1小时的热处理。经过碱处理和热处理后，以及随后浸泡在模拟体液（SBF）中后，使用配备能量色散电子探针X射线分析仪的扫描电子显微镜检查试样表面的形态和成分变化。结果显示，浸泡在SBF溶液中的处理后基体表面形成了致密且均匀的骨样磷灰石层。在大鼠体内进行了研究，以评估碱处理和热处理后的Ti-6Al-7Nb和Ti-5Al-2Nb-1Ta合金表面的骨传导性，并与未处理的钛合金作为对照。从这些材料制备了以下钛植入物：（1）无植入物对照；（2）未处理的钛植入物；（3）碱处理和热处理的植入物——将植入物在60℃下浸入10M的NaOH溶液中24小时，随后在600℃下加热1小时。将试样插入大鼠每条胫骨的内侧。组织学检查表明，碱热处理的植入物与植入物表面的直接骨接触明显高于未处理的钛植入物。
