Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA.
Biofactors. 2010 Nov-Dec;36(6):430-6. doi: 10.1002/biof.117. Epub 2010 Aug 27.
For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment.
在过去的 100 年中,维生素 A 一直被认为是宿主抵抗传染病的必需膳食成分。然而,直到最近,研究才开始阐明维生素 A 调节细胞介导和体液免疫的细胞和分子机制。在这篇综述中,我们概述了最近发现的维生素 A 及其代谢产物视黄酸 (RA) 在免疫细胞调节中的作用。特别关注炎症反应和实体瘤微环境,讨论了 RA 如何影响白细胞的生长、分化和归巢。