Department of Pediatrics, Medical University of Silesia, 3-Maja, Zabrze, Poland.
Pediatr Allergy Immunol. 2012 May;23(3):278-84. doi: 10.1111/j.1399-3038.2011.01225.x. Epub 2011 Oct 21.
Thymus and activation-regulated chemokine (TARC/CCL17) and cutaneous T cell-attracting chemokine (CTACK/CCL27) belong to the CC chemokine family, which plays an important role in immune-inflammatory processes. It has been demonstrated that serum concentrations of TARC and CTACK are increased in patients with various allergic diseases.
To compare serum TARC and CTACK concentrations between children with different clinical manifestation of mast cell-dependent diseases, such as atopic allergy and urticaria.
A total of 87 children including 26 with mild to severe atopic dermatitis (AD), 43 children with controlled allergic asthma symptoms (treated and untreated with anti-inflammatory drugs), and 18 children with urticaria were recruited into the study. The control group consisted of 31 healthy non-atopic children.
Serum concentrations of TARC and CTACK were significantly higher in children with AD than in healthy controls. No significant differences in serum concentrations of the chemokines between asthmatics, urticaria patients, and healthy controls were found. The severity of AD symptoms significantly correlated with serum CTACK and TARC concentrations.
These findings, in conjunction with earlier data, indicate that differences may exist in circulating concentrations of TARC and CTACK, between patients with atopic allergy and urticaria.
胸腺和活化调节趋化因子（TARC/CCL17）和皮肤 T 细胞吸引趋化因子（CTACK/CCL27）属于 CC 趋化因子家族，在免疫炎症过程中发挥重要作用。已经证明，各种过敏性疾病患者的血清 TARC 和 CTACK 浓度增加。
比较不同临床表现的肥大细胞依赖性疾病（如特应性过敏和荨麻疹）患儿的血清 TARC 和 CTACK 浓度。
共招募了 87 名儿童，包括 26 名轻度至重度特应性皮炎（AD）患儿、43 名过敏性哮喘症状得到控制的儿童（接受和未接受抗炎药物治疗）和 18 名荨麻疹患儿。对照组由 31 名非特应性健康儿童组成。
AD 患儿血清 TARC 和 CTACK 浓度明显高于健康对照组。哮喘患儿、荨麻疹患者和健康对照组之间的趋化因子血清浓度无显著差异。AD 症状的严重程度与血清 CTACK 和 TARC 浓度显著相关。
这些发现与早期数据相结合表明，特应性过敏和荨麻疹患者循环 TARC 和 CTACK 浓度可能存在差异。
Zotero 插件