Berk David R, Miller Alicia, Scarlett Debra, Wippold Franz J, Bayliss Susan J, Lu Dongsi
Department of Internal Medicine, Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA.
Dermatol Online J. 2010 Aug 15;16(8):3.
Osseous metaplasia has recently been described in several cases of nephrogenic systemic fibrosis, sometimes in association with unusual clinical features such as painful hyperkeratotic spicules, palpable bony masses, and disease regression. Some authors have suggested that it may mainly occur late in the disease course or even be a marker for involuting nephrogenic systemic fibrosis. Here, we present a 27-year-old woman with a 7-year history of nephrogenic systemic fibrosis, who developed cutaneous osseous metaplasia.
骨化生最近在几例肾源性系统性纤维化病例中被描述，有时伴有异常的临床特征，如疼痛性角化过度性棘状突起、可触及的骨块和疾病消退。一些作者认为，它可能主要发生在疾病病程后期，甚至可能是肾源性系统性纤维化消退的一个标志。在此，我们报告一名患有肾源性系统性纤维化7年的27岁女性，她出现了皮肤骨化生。
