Le Corre Y, Steff M, Prophette B, Celerier P, Maillard H
Service de dermatologie, centre hospitalier du Mans, 72000 Le-Mans, France.
Ann Dermatol Venereol. 2010 Aug-Sep;137(8-9):532-5. doi: 10.1016/j.annder.2009.04.014. Epub 2009 May 28.
Annular elastolytic giant-cell granuloma (AEGCG) is a rare form of granulomatous dermatosis characterized by annular plaques with central atrophy and raised erythematous margins and is usually located on the facial and neck areas. It is characterized histologically by loss of elastic fibre and elastophagocytosis. We report a case of AEGCG.
A 72-year-old man consulted for annular plaques, some of which were atrophic, and papules that had been present for 2 years. The lesions involved sun-exposed and non-sun-exposed skin. The biopsies showed granulomatous infiltrates and discrete elastophagocytosis. After ruling out various differential clinical and histological diagnoses, the patient was diagnosed with AEGCG.
We report a case of AEGCG. Diagnosis was not easy. The differential diagnoses of this entity were discussed and we ruled out actinic granuloma, sarcoidosis, leprosy, and granuloma annulare. Our patient presented the classical annular variant combined with a papular variant. We report the first case involving response to isotretinoin.
环状弹性组织溶解性巨细胞肉芽肿(AEGCG)是一种罕见的肉芽肿性皮肤病,其特征为具有中央萎缩和隆起红斑边缘的环状斑块,通常位于面部和颈部区域。其组织学特征为弹性纤维丧失和弹性组织吞噬作用。我们报告一例AEGCG病例。
一名72岁男性因出现环状斑块(其中一些有萎缩)和丘疹前来就诊,这些症状已持续2年。病变累及暴露于阳光和未暴露于阳光的皮肤。活检显示肉芽肿浸润和散在的弹性组织吞噬作用。在排除各种不同的临床和组织学诊断后,该患者被诊断为AEGCG。
我们报告一例AEGCG病例。诊断并不容易。讨论了该疾病的鉴别诊断,我们排除了光化性肉芽肿、结节病、麻风病和环状肉芽肿。我们的患者表现为经典的环状变型合并丘疹变型。我们报告了首例对异维A酸有反应的病例。