Department of Dermatology, Medical University of Warsaw, Poland.
Endokrynol Pol. 2010 Jul-Aug;61(4):406-11.
Hair loss may accompany several endocrine disorders, including hypopituitarism, hypothyreosis, hyperthyreosis, hypoparathyroidism, diabetes mellitus, growth hormone deficiency, hyperprolactinaemia, polycystic ovary syndrome, SAHA syndrome, congenital adrenal hyperplasia, Cushing syndrome, or virilising tumours. Most patients with endocrine disorders present with diffuse non-scarring alopecia, such as anagen effluvium, telogen effluvium or androgenetic alopecia. Focal non-scarring alopecia, such as alopecia areata coexisting with autoimmune thyroiditis, is less frequent and scarring alopecia is a rare finding in patients with endocrine abnormalities. In some cases an endocrine disorder may be suspected based on dermatological findings during hair loss evaluation. Classic methods of hair evaluation include hair weighing, pull test, wash test, the trichogram, and histopathological examination. Newly developed non-invasive diagnostic techniques include the phototrichogram, trichoscan, trichoscopy, and reflectance confocal microscopy.
脱发可伴有几种内分泌紊乱,包括垂体功能减退症、甲状腺功能减退症、甲状腺功能亢进症、甲状旁腺功能减退症、糖尿病、生长激素缺乏症、高催乳素血症、多囊卵巢综合征、SAHA 综合征、先天性肾上腺皮质增生症、库欣综合征或男性化肿瘤。大多数内分泌紊乱的患者表现为弥漫性非瘢痕性脱发,如生长期脱发、休止期脱发或雄激素性脱发。局灶性非瘢痕性脱发,如伴有自身免疫性甲状腺炎的斑秃,则较为少见,瘢痕性脱发在内分泌异常患者中罕见。在某些情况下,脱发评估过程中根据皮肤科发现可怀疑存在内分泌紊乱。经典的毛发评估方法包括毛发称重、拔毛试验、洗发试验、毛发横切和组织病理学检查。新开发的非侵入性诊断技术包括光电发密度仪、毛发扫描、毛发镜检和反射共聚焦显微镜。
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