抽动秽语综合征的神经生物学基础。
Neurobiological substrates of Tourette's disorder.
作者信息
Leckman James F, Bloch Michael H, Smith Megan E, Larabi Daouia, Hampson Michelle
机构信息
Child Study Center, Yale University, New Haven, Connecticut 06520-7900, USA.
出版信息
J Child Adolesc Psychopharmacol. 2010 Aug;20(4):237-47. doi: 10.1089/cap.2009.0118.
OBJECTIVE
This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD).
METHODS
The electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies using relevant search terms.
RESULTS
Neuropathological as well as structural and functional neuroimaging studies of TD implicate not only the sensorimotor corticostriatal circuit, but also the limbic and associative circuits as well. Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control. Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation.
CONCLUSION
Structural and functional abnormalities in multiple parallel corticostriatal circuits may underlie the behavioral manifestations of TD and related neuropsychiatric disorders over the course of development. Further longitudinal research is needed to elucidate these neurobiological substrates.
目的
本文综述了有关抽动秽语障碍（TD）神经生物学基础的现有科学文献。
方法
使用相关检索词在PubMed、ScienceDirect和PsycINFO电子数据库中搜索相关研究。
结果
TD的神经病理学以及结构和功能神经影像学研究不仅涉及感觉运动皮质纹状体回路，还涉及边缘系统和联合回路。初步证据还表明，负责维持适应性在线控制的额顶叶网络存在异常。尽管确切机制仍有待推测，但支持多巴胺能和去甲肾上腺素能神经传递异常的证据依然充分。
结论
多个平行皮质纹状体回路的结构和功能异常可能是TD及相关神经精神障碍在发育过程中行为表现的基础。需要进一步开展纵向研究以阐明这些神经生物学基础。
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