Wong David M, Alcott Cody J, Wang Chong, Hay-Kraus Bonnie L, Buchanan Benjamin R, Brockus Charles W
Section of Equine Medicine, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Am J Vet Res. 2010 Sep;71(9):1081-8. doi: 10.2460/ajvr.71.9.1081.
To evaluate the effects of various flow rates of oxygen administered via 1 or 2 nasal cannulae on the fraction of inspired oxygen concentration (FIO2) and other arterial blood gas variables in healthy neonatal foals.
9 healthy neonatal (3- to 4-day-old) foals.
In each foal, a nasal cannula was introduced into each naris and passed into the nasopharynx to the level of the medial canthus of each eye; oxygen was administered at 4 flow rates through either 1 or both cannulae (8 treatments/foal). Intratracheal FIO2, intratracheal end-tidal partial pressure of carbon dioxide, and arterial blood gas variables were measured before (baseline) and during unilateral and bilateral nasopharyngeal delivery of 50, 100, 150, and 200 mL of oxygen/kg/min.
No adverse reactions were associated with administration of supplemental oxygen except at the highest flow rate, at which the foals became agitated. At individual flow rates, significant and dose-dependent increases in FIO2, PaO2, and oxygen saturation of hemoglobin (SaO2) were detected, compared with baseline values. Comparison of unilateral and bilateral delivery of oxygen at similar cumulative flow rates revealed no differences in evaluated variables.
Results indicated that administration of supplemental oxygen via nasal cannulae appeared to be a highly effective means of increasing FIO2, PaO2, and SaO2 in neonatal foals. These findings may provide guidance for implementation of oxygen treatment in hypoxemic neonatal foals.
评估经1根或2根鼻导管给予不同氧流量对健康新生马驹吸入氧浓度（FIO2）及其他动脉血气变量的影响。
9匹健康新生（3至4日龄）马驹。
给每匹马驹的每个鼻孔插入一根鼻导管并送入鼻咽部至每只眼睛内眦水平；通过1根或2根导管以4种流量给予氧气（每匹马驹8种处理）。在单侧和双侧鼻咽部输送50、100、150和200 mL氧/千克/分钟之前（基线）以及过程中，测量气管内FIO2、气管内呼气末二氧化碳分压和动脉血气变量。
除最高流量时马驹变得烦躁不安外，补充氧气未引起不良反应。与基线值相比，在各个流量下，均检测到FIO2、动脉血氧分压（PaO2）和血红蛋白氧饱和度（SaO2）显著且呈剂量依赖性增加。在相似累积流量下比较单侧和双侧输氧情况，所评估变量无差异。
结果表明，经鼻导管给予补充氧气似乎是提高新生马驹FIO2、PaO2和SaO2的一种高效方法。这些发现可为低氧血症新生马驹的氧疗实施提供指导。
