Serviço de Endocrinologia e Metabologia, Hospital das Clínicas da Faculdade de Medicina da Universidade, São Paulo, SP, Brazil.
Gynecol Endocrinol. 2011 Oct;27(10):814-9. doi: 10.3109/09513590.2010.508852. Epub 2010 Sep 1.
One hundred forty-two women with polycystic ovary syndrome (PCOS) with an average body mass index (BMI) of 29.1 kg/m(2) and average age of 25.12 years were studied. By BMI, 30.2% were normal, 38.0% were overweight and 31.6% were obese. Thirty-one eumenorrheic women matched for BMI and age, with no evidence of hyperandrogenism, were recruited as controls. The incidence of dyslipidemia in the PCOS group was twice that of the Control group (76.1% versus 32.25%). The most frequent abnormalities were low high-density lipoprotein cholesterol (HDL-C; 57.6%) and high triglyceride (TG) (28.3%). HDL-C was significantly lower in all subgroups of women with PCOS when compared to the subgroups of normal women. No significant differences were seen in the total cholesterol (p = 0.307), low-density lipoprotein cholesterol (LDL-C; p = 0.283) and TGs (p = 0.113) levels among the subgroups. An independent effect on HDL-C was detected for glucose (p = 0.004) and fasting insulin (p = 0.01); on TG for age (p = 0.003) and homeostatic model assessment insulin resistance (p = 0.03) and on total cholesterol and LDL-C for age (p = 0.02 and p = 0.033, respectively). In conclusion, dyslipidemia is common in women with PCOS, mainly due to low HDL-C levels. BMI has a significant impact on this abnormality.
本研究纳入了 142 名多囊卵巢综合征（PCOS）女性患者，平均 BMI 为 29.1kg/m²，平均年龄为 25.12 岁。根据 BMI，30.2%的患者为正常体重，38.0%为超重，31.6%为肥胖。同期纳入了 31 名年龄和 BMI 匹配、无高雄激素血症证据的月经正常女性作为对照组。与对照组（32.25%）相比，PCOS 组的血脂异常发生率为对照组的两倍（76.1%）。最常见的异常是低高密度脂蛋白胆固醇（HDL-C；57.6%）和高三酰甘油（TG）（28.3%）。与正常女性亚组相比，所有 PCOS 女性亚组的 HDL-C 均显著降低。各组间总胆固醇（p = 0.307）、低密度脂蛋白胆固醇（LDL-C；p = 0.283）和 TG（p = 0.113）水平无显著差异。葡萄糖（p = 0.004）和空腹胰岛素（p = 0.01）对 HDL-C 有独立影响；年龄对 TG（p = 0.003）和稳态模型评估胰岛素抵抗（HOMA-IR；p = 0.03）有独立影响，年龄对总胆固醇和 LDL-C 有独立影响（p = 0.02 和 p = 0.033）。综上所述，血脂异常在 PCOS 女性中很常见，主要是由于 HDL-C 水平降低。BMI 对这种异常有显著影响。
