Buijs J, Egbers M W, Nijkamp F P
Inst. of Public Health and Environmental Hygiene, Lab. Parasitology and Mycology, Bilthoven, The Netherlands.
Agents Actions Suppl. 1990;31:75-80. doi: 10.1007/978-3-0348-7379-6_9.
Migrating larvae of the canine nematode Toxocara canis induce inflammatory responses in the lungs of infected mice. Histological examination of the lungs showed that mice, developed persistent multifocal inflammation in which eosinophils (eos), macrophages (M phi) and many lymphocytes were involved. Cuffing of blood vessels and bronchioles with mixed cell populations was also observed. Investigation into the response of isolated tracheae to cholinergic and beta-adrenergic receptor agonists demonstrated a significant decreased reactivity despite the pronounced involvement of eos and M phi. This hyporeactive state persisted for greater than or equal to 4 weeks p.i..
犬线虫犬弓首蛔虫的移行幼虫可在受感染小鼠的肺部诱发炎症反应。对肺部进行组织学检查发现，小鼠出现持续性多灶性炎症，其中涉及嗜酸性粒细胞（eos）、巨噬细胞（M phi）和许多淋巴细胞。还观察到血管和细支气管周围有混合细胞群形成套袖状。对分离的气管对胆碱能和β-肾上腺素能受体激动剂的反应进行研究发现，尽管嗜酸性粒细胞和巨噬细胞明显参与其中，但反应性显著降低。这种低反应状态在感染后持续≥4周。
