Department of General Biology and Parasitology, Biostructure Centre, Medical University of Warsaw, Warsaw, Poland.
Parasite Immunol. 2012 Oct;34(10):455-63. doi: 10.1111/j.1365-3024.2012.01381.x.
Trichinella spiralis and Toxocara canis larvae migrated through the lung and induced many alterations in the lung parenchyma. Using electron microscopy, we identified and described the histopathological changes. These changes resulted from mechanical damage or from local inflammatory reactions provoked by larvae. The pattern of changes was described between 6 and 12 days post-infection (DPI) with T. spiralis larvae, and between 21 and 28 DPI with T. canis. The ultrastructural studies demonstrated that T. spiralis larvae migrating through the lungs evoked mainly destruction of type I epithelial cells, destruction of lamellar bodies of epithelial cells or extracellular alveolar lining layer. The severity of these changes was dependent on the number of infective larvae (400 or 800 T. spiralis larvae) and possibly the result of mechanical damage in the lung parenchyma. In contrast, infection with T. canis larvae initiated mainly eosinophilic perivasculitis and vasculitis as well as macrophage accumulation in the lung, which were additionally impacted by numerous crystalloid inclusions in macrophages. Trichinella spiralis larvae and T. canis larvae induced different pathological changes in the lungs of infected mice.
旋毛虫和犬蛔虫幼虫迁移通过肺部，并在肺实质中引起许多改变。使用电子显微镜，我们鉴定并描述了组织病理学变化。这些变化是由幼虫引起的机械损伤或局部炎症反应引起的。在感染旋毛虫幼虫后 6 至 12 天（DPI）和感染犬蛔虫后 21 至 28 天（DPI）之间描述了变化模式。超微结构研究表明，通过肺部迁移的旋毛虫幼虫主要引起 I 型上皮细胞的破坏、上皮细胞板层体的破坏或细胞外肺泡衬里层的破坏。这些变化的严重程度取决于感染性幼虫的数量（400 或 800 条旋毛虫幼虫），并且可能是肺实质中机械损伤的结果。相比之下，感染犬蛔虫幼虫主要引发嗜酸性血管周炎和血管炎以及肺内巨噬细胞聚集，此外，巨噬细胞中还存在大量结晶包涵体。旋毛虫幼虫和犬蛔虫幼虫在感染小鼠的肺部引起不同的病理变化。
