Department of Psychiatry, Hairmyres Hospital, East Kilbride, UK.
Br J Psychiatry. 2010 Sep;197(3):244-5. doi: 10.1192/bjp.bp.108.054072.
Pernicious anaemia can present with psychiatric symptoms before haematological or neurological manifestations appear. We describe a young woman who presented with insidious onset catatonia without evidence of psychosis or depression. Blood count and mean cell volume were normal and neurological findings were equivocal. Low B(12) levels and intrinsic factor antibodies were found only by chance when they were included in a battery of further investigations. B(12) replacement was followed by prompt improvement. This case provides an argument for wider screening for B(12) deficiency in certain individuals with psychiatric disorders.
恶性贫血可在出现血液学或神经系统表现之前出现精神症状。我们描述了一位年轻女性，她以隐匿性起病的紧张症起病，无精神病或抑郁症的证据。血常规和平均红细胞体积正常，神经系统检查结果不确定。只有在进一步检查时偶然发现低 B(12)水平和内因子抗体。补充 B(12)后迅速改善。该病例为某些有精神障碍的个体广泛筛查 B(12)缺乏提供了依据。
