Molloy A, Cawley N, Ali E, Connolly S, Tubridy N, Hutchinson M
Department of Neurology, St Vincent's University Hospital, Elm Park, Dublin 4.
Ir Med J. 2009 Oct;102(9):292-4.
Pernicious anaemia may manifest various neurological symptoms and signs ranging from the subtle to the dramatic. We describe a young man with cobalamin deficiency presenting with sensorimotor deficits, ataxia, dysarthria, mild cognitive deterioration and altered mood of insidious onset. The MRI brain findings were in keeping with a leucoencephalopathy without evidence of MRI changes in the spinal cord. This constellation of features has been reported rarely. His response to treatment as well as the marked improvement of the leucoencephalopathy on imaging suggests at least partial reversibility of the neurological deficits.
恶性贫血可能表现出各种神经系统症状和体征，从轻微到严重不等。我们描述了一名患有钴胺素缺乏症的年轻男性，他出现了感觉运动障碍、共济失调、构音障碍、轻度认知衰退和隐匿起病的情绪改变。脑部MRI检查结果符合白质脑病，脊髓未发现MRI改变。这种特征组合很少有报道。他对治疗的反应以及影像学上白质脑病的明显改善表明神经功能缺损至少有部分可逆性。
