Stark P, Gergs P, Nolte H
Anaesthesist. 1977 Aug;26(8):395-7.
The ph-changes of cerebral spinal fluid were measured following subarachnoid injection of bupivacaine 0.5% with and without adrenaline (1:200,000) during the three hours after the start of anaesthesia. At the same time drug precipitation was not detected. The ph-changes however, were pronounced but not enough to cause disturbances of the homoeostatic milieu. Especially no significant differences related to adrenaline were be found. The authors recommend bupivacaine 0.5% with and without adrenaline for spinal anaesthesia.
在麻醉开始后的三小时内，测量了蛛网膜下腔注射含和不含肾上腺素（1:200,000）的0.5%布比卡因后脑脊液的pH变化。同时未检测到药物沉淀。然而，pH变化显著，但不足以引起内环境稳态的紊乱。尤其未发现与肾上腺素相关的显著差异。作者推荐使用含和不含肾上腺素的0.5%布比卡因进行脊髓麻醉。
