Biscoping J, Ahlbrecht R, Salomon F, Hempelmann G
Reg Anaesth. 1983 Oct;6(4):76-9.
In 20 patients, undergoing total hip or knee replacement, we studied pH and metabolic changes in the C.S.F. following spinal anaesthesia with two different mixtures of bupivacaine 0.5% and mepivacaine 4% hyperbaric. Our study was made with special regard to the early changes; therefore C.S.F. specimens were obtained at 1, 3, 5, 10, 20, 30, 60 and 90 min intervals and analyses of pH, pCO2, HCO3 and BE estimations were carried out immediately after each obtained sample. Our results showed a marked tendency towards acidosis and therefore do not comply with previous studies. The advantage of this fact is an improved stability of bupivacaine in C.S.F.
在20例行全髋关节或全膝关节置换术的患者中，我们研究了在蛛网膜下腔麻醉下使用两种不同混合比例的0.5%布比卡因和4%重比重甲哌卡因后，脑脊液中的pH值和代谢变化。我们的研究特别关注早期变化；因此，每隔1、3、5、10、20、30、60和90分钟采集脑脊液样本，并在每次采集样本后立即进行pH值、二氧化碳分压、碳酸氢根和碱剩余的分析。我们的结果显示出明显的酸中毒倾向，因此与先前的研究结果不符。这一事实的好处是布比卡因在脑脊液中的稳定性得到了提高。
