Department of Pediatrics, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
J Atheroscler Thromb. 2010 Nov 27;17(11):1167-75. doi: 10.5551/jat.5264. Epub 2010 Aug 27.
Little is known about the impact of having one cardiovascular (CV) risk factor on the levels of other CV risk factors in the general adolescent population. We hypothesized that when adolescents have one CV risk factor, the levels of other CV risk factors worsen simultaneously.
Subjects consisted of 1,257 healthy adolescent volunteers (549 males and 708 females) aged 15-18 years. Abdominal obesity, hypertension, raised triglyceride levels, decreased HDL-cholesterol levels and hyperglycemia were used as CV risk factors. Homeostasis assessment of insulin resistance (HOMA-IR) was used as a surrogate marker of insulin resistance. Levels of four biomarkers, leptin, adiponectin, high-sensitive C-reactive protein, and desacyl-ghrelin, were also determined. Cut-offs for gender-specific individual CV risk factor levels were based on the 90th (or 10th) percentile values of the subjects in the present study.
The levels of all CV risk factors and HOMA-IR significantly and simultaneously worsened when adolescents had one CV risk factor in both genders. Having any one CV risk factor indicated the development of other CV risk factors in adolescents; in particular, we found that the development of abdominal obesity in male subjects had a harmful effect on the levels of other CV risk factors and was associated with the worsening of all four biomarkers examined.
It is important to determine the presence or absence of these CV risk factors before and/or during adolescence, because having one CV risk factor indicates the start of an accumulation of CV risk factors in the general adolescent population.
对于一般青少年人群，尚不清楚存在一个心血管（CV）危险因素对其他 CV 危险因素水平的影响。我们假设当青少年存在一个 CV 危险因素时，其他 CV 危险因素的水平会同时恶化。
研究对象为 1257 名年龄在 15-18 岁的健康青少年志愿者（549 名男性和 708 名女性）。将腹部肥胖、高血压、甘油三酯水平升高、高密度脂蛋白胆固醇水平降低和高血糖作为 CV 危险因素。稳态评估胰岛素抵抗（HOMA-IR）被用作胰岛素抵抗的替代标志物。还测定了四种生物标志物，瘦素、脂联素、高敏 C 反应蛋白和去酰化胃饥饿素的水平。基于本研究中个体 CV 危险因素水平的第 90（或第 10）个百分位数值，为性别特异性个体 CV 危险因素水平设定了截止值。
当青少年在两性中存在一个 CV 危险因素时，所有 CV 危险因素和 HOMA-IR 的水平均显著且同时恶化。存在任何一个 CV 危险因素表明青少年中存在其他 CV 危险因素；特别是，我们发现男性受试者中腹部肥胖的发生对其他 CV 危险因素水平有不良影响，并与所检查的所有四种生物标志物的恶化有关。
在青春期之前和/或期间确定这些 CV 危险因素的存在与否很重要，因为存在一个 CV 危险因素表明一般青少年人群中 CV 危险因素的积累开始。
