Departments of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan.
Am J Geriatr Psychiatry. 2010 Nov;18(11):1045-8. doi: 10.1097/JGP.0b013e3181dba6f1.
The main aim of this study was to examine the symptomatology of major depression in Alzheimer disease (AD) and its relationship with plasma homocysteine level.
Eighty-three patients with AD were enrolled for clinical assessments and examination of fasting plasma homocysteine. Diagnosis of major depression was made, and the severity of the depression was assessed.
The moderate dementia patients presented with more common behavioral disturbances related to major depression than mild dementia patients. Major depression in patients with moderate AD was associated with higher plasma homocysteine levels. Furthermore, a high plasma homocysteine level was positively associated with behavioral disturbance among study participants with major depression.
More behavioral disturbance associated with major depression occurred as the dementia progressed. Patients with a higher level of plasma homocysteine presented with a higher behavioral disturbance symptomatology. This finding may account for the relationship between elevated homocysteine levels and depression only in patients with moderate AD.
本研究的主要目的是探讨阿尔茨海默病（AD）中重度抑郁症的症状及其与血浆同型半胱氨酸水平的关系。
共纳入 83 例 AD 患者进行临床评估和空腹血浆同型半胱氨酸检查。诊断为重度抑郁症，并评估其严重程度。
中度痴呆患者比轻度痴呆患者表现出更多与重度抑郁症相关的常见行为障碍。中度 AD 患者的重度抑郁症与较高的血浆同型半胱氨酸水平相关。此外，研究参与者中血浆同型半胱氨酸水平较高与行为障碍呈正相关。
随着痴呆的进展，与重度抑郁症相关的行为障碍更为常见。血浆同型半胱氨酸水平较高的患者表现出更高的行为障碍症状。这一发现可能仅在中度 AD 患者中解释了同型半胱氨酸水平升高与抑郁症之间的关系。
