Baggot J D
Irish Equine Centre, Johnstown, County Kildare.
Ann Rech Vet. 1990;21 Suppl 1:29S-40S.
The dose-effect relationship can be determined by linking pharmacokinetic drug behavior with information on pharmacodynamic activity. This requires that the quantifiable concentrations of drug (or metabolites) in the plasma (systemic circulation) are related to the concentration at the site of action. Using the pharmacokinetic parameters and a pharmacokinetic-pharmacodynamic model, it is possible to predict the pharmacodynamic response to certain drugs; this provides useful information for understanding drug action and to determine dosage regimen.
通过将药物的药代动力学行为与药效学活性信息联系起来，可以确定剂量-效应关系。这需要血浆（体循环）中可量化的药物（或代谢物）浓度与作用部位的浓度相关联。利用药代动力学参数和药代动力学-药效学模型，可以预测对某些药物的药效学反应；这为理解药物作用和确定给药方案提供了有用信息。
