Faculty of Medicine, University of Alberta, Edmonton, Alberta;
Can J Infect Dis Med Microbiol. 2009 Fall;20(3):73-7. doi: 10.1155/2009/901372.
There are limited recent data on rubella immunity in women of childbearing age in Canada. In the present paper, the proportion of rubella seroreactivity and redundant testing (testing of women previously seropositive when tested by the same physician) in the Alberta prenatal rubella screening program were studied.
In the present retrospective observational study, data on all specimens submitted for prenatal screening in Alberta between August 2002 and December 2005 were extracted from the Provincial Laboratory for Public Health database. The proportion of rubella screening and immunoglobulin G (IgG) seroreactivity were determined. Demographic variables were compared between rubella seroreactors and nonseroreactors. The proportion of redundant testing was determined.
Of 159,046 prenatal specimens, 88.3% (n=140,473) were screened for rubella immunity. In total, 8.8% of specimens tested negative for rubella IgG. Younger women (23.2% of women younger than 20 years of age versus 4.7% of women between 35 and 39 years of age; P<0.001) and women from northern Alberta (11.9% versus 8.1% [overall]; P<0.001) were significantly more likely to have seronegative specimens. Of the 20,044 women who had multiple rubella immunity screenings, 88.1% (n=17,651) had multiple positive test results. In total, 20.7% of the 42,274 specimens submitted from women with multiple screenings were deemed redundant.
Younger women were most likely to be seronegative for rubella. The public health significance of women entering their childbearing years with low or undetectable rubella IgG levels remains to be determined. A large number of women with documented rubella immunity were unnecessarily retested.
加拿大育龄妇女的风疹免疫情况近期数据有限。本文研究了艾伯塔省产前风疹筛查计划中的风疹血清反应率和重复检测（当同一医生检测时，对以前血清阳性的妇女进行检测）的比例。
在本回顾性观察研究中，从省级公共卫生实验室数据库中提取了 2002 年 8 月至 2005 年 12 月期间艾伯塔省所有提交产前筛查的标本数据。确定了风疹筛查和免疫球蛋白 G（IgG）血清反应率。比较了风疹血清反应者和非血清反应者的人口统计学变量。确定了重复检测的比例。
在 159046 份产前标本中，88.3%（n=140473）进行了风疹免疫力筛查。共有 8.8%的标本风疹 IgG 检测结果为阴性。年轻女性（20 岁以下女性的 23.2%，35-39 岁女性的 4.7%；P<0.001）和来自艾伯塔省北部的女性（11.9%比 8.1%[总体]；P<0.001）更有可能出现血清阴性标本。在 20044 名多次接受风疹免疫筛查的女性中，88.1%（n=17651）有多次阳性检测结果。共有 42274 份来自多次筛查女性的标本被认为是多余的，占总数的 20.7%。
年轻女性最有可能对风疹血清阴性。女性进入生育年龄时风疹 IgG 水平较低或无法检测到，其公共卫生意义仍有待确定。大量有风疹免疫记录的妇女被不必要地重复检测。
