大鼠肝脏微粒体对1H-苯并三唑羧酸酯的水解和氧化作用。
Hydrolysis and oxidation of 1H-benzotriazole-carboxylic acid esters by rat liver microsomes.
作者信息
Jacobi S, Hoffmann H
机构信息
Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität, Frankfurt am Main.
出版信息
Arch Pharm (Weinheim). 1990 Oct;323(10):825-7. doi: 10.1002/ardp.19903231002.
PMID:2080893
Abstract
The 1H-benzotriazole-carboxylic acid esters under investigation were almost - with the exception of the tert.-butylester - completely hydrolyzed by rat liver microsomes. Some substrates were metabolically oxidized to a very small extent (less than 1%) yielding small amounts of possibly toxic metabolites after inhibition of the esterases with paraoxone.
摘要
所研究的1H-苯并三唑羧酸酯类物质，除叔丁酯外，几乎都能被大鼠肝微粒体完全水解。在使用对氧磷抑制酯酶后，一些底物会发生极少量（小于1%）的代谢氧化，产生少量可能有毒的代谢产物。
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