Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Wien Klin Wochenschr. 2010 Sep;122(17-18):519-24. doi: 10.1007/s00508-010-1426-x. Epub 2010 Sep 3.
To explore the serum anti-mullerian hormone (AMH) level in adolescent and young adult Chinese patients with polycystic ovary syndrome (PCOS), and to evaluate its diagnostic value for PCOS.
Serum AMH was measured in a cohort of 47 adolescent and young adult Chinese patients with PCOS and 40 age-matched controls. Its diagnostic potential was evaluated by Receiver Operating Characteristic (ROC) curves.
The serum AMH level was higher in PCOS patients than in controls (9.85 ± 4.93 ng/mL vs. 7.13 ± 3.02 ng/mL, P = 0.002), and positively related to the mean ovarian volume in PCOS patients (r = 0.319, P = 0.029). The area under the ROC curve for AMH reached a value of 0.664 (0.551-0.778, 95% confidence interval). The best compromise between specificity (70%) and sensitivity (61.7%) was obtained with a cut-off value of 8 ng/mL.
Serum AMH levels are elevated in adolescent and young adult Chinese patients of PCOS. Serum AMH measurement offers a relatively poor diagnostic potency with a sensitivity of 61.7% and a specificity of 70% at 8 ng/mL.
探讨青春期和年轻成年的多囊卵巢综合征（PCOS）中国患者的血清抗苗勒管激素（AMH）水平，并评估其对 PCOS 的诊断价值。
对 47 例青春期和年轻成年的多囊卵巢综合征中国患者和 40 例年龄匹配的对照者进行了队列研究，检测了其血清 AMH 水平。通过接收者操作特征（ROC）曲线评估其诊断潜能。
PCOS 患者的血清 AMH 水平高于对照组（9.85±4.93ng/ml 比 7.13±3.02ng/ml，P=0.002），与 PCOS 患者的平均卵巢体积呈正相关（r=0.319，P=0.029）。AMH 的 ROC 曲线下面积为 0.664（0.551-0.778，95%置信区间）。以 8ng/ml 为截断值，特异性（70%）和敏感性（61.7%）之间达到最佳平衡。
青春期和年轻成年的多囊卵巢综合征中国患者的血清 AMH 水平升高。血清 AMH 检测的诊断效能相对较差，以 8ng/ml 为截断值时，敏感性为 61.7%，特异性为 70%。
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