Matsuzaki Toshiya, Munkhzaya Munkhsaikhan, Iwasa Takeshi, Tungalagsuvd Altankhuu, Yano Kiyohito, Mayila Yiliyasi, Yanagihara Rie, Tokui Takako, Kato Takeshi, Kuwahara Akira, Matsui Sumika, Irahara Minoru
Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
Endocr J. 2017 May 30;64(5):531-541. doi: 10.1507/endocrj.EJ16-0501. Epub 2017 Apr 1.
Polycystic ovary syndrome (PCOS) is an ovulatory disorder that affects 6-10% of women of reproductive age. Serum AMH level may be an additional factor, or surrogate of PCOM, in the diagnostic criteria of PCOS. We evaluated the correlations between the serum AMH level and various endocrine and metabolic features in PCOS using the latest fully automated assay. Serum AMH level was compared between 114 PCOS patient (PCOS group) and 95 normal menstrual cycle women (Control group). Correlations between serum AMH level and various endocrine and metabolic factors were analysed in PCOS group. The serum AMH level was significantly higher in the PCOS group (8.35±8.19 ng/mL) than in the Control group (4.99±3.23 ng/mL). The serum AMH level was independently affected by age and the presence of PCOS on multiple regression analysis. Ovarian volume per ovary (OPVO) showed the strongest positive correlation (r=0.62) with the serum AMH level among related factors. On receiver operating characteristic (ROC) curve analysis, the cut-off value of AMH for the diagnosis of PCOS was 7.33 ng/mL, but this value did not have high efficacy (sensitivity 44.7%, specificity 76.8%). A cut-off value of 10 ng/mL had a high specificity of 92.6%, although the sensitivity was low (24.6%). The serum AMH level was elevated and reflected ovarian size in PCOS patients. The serum AMH level could be a surrogate for ultrasound findings of the ovaries in PCOS and might be useful for estimating ovarian findings without transvaginal ultrasound in the diagnosis of PCOS.
多囊卵巢综合征（PCOS）是一种排卵障碍疾病，影响6% - 10%的育龄女性。血清抗缪勒管激素（AMH）水平可能是PCOS诊断标准中的一个附加因素或多囊卵巢形态（PCOM）的替代指标。我们使用最新的全自动检测方法评估了PCOS患者血清AMH水平与各种内分泌和代谢特征之间的相关性。比较了114例PCOS患者（PCOS组）和95例月经周期正常女性（对照组）的血清AMH水平。分析了PCOS组血清AMH水平与各种内分泌和代谢因素之间的相关性。PCOS组的血清AMH水平（8.35±8.19 ng/mL）显著高于对照组（4.99±3.23 ng/mL）。多元回归分析显示，血清AMH水平独立受年龄和PCOS的存在影响。在相关因素中，每侧卵巢体积（OPVO）与血清AMH水平的正相关性最强（r = 0.62）。在受试者工作特征（ROC）曲线分析中，AMH诊断PCOS的截断值为7.33 ng/mL，但该值的诊断效能不高（敏感性44.7%，特异性76.8%）。截断值为10 ng/mL时，特异性高达92.6%，但敏感性较低（24.6%）。PCOS患者的血清AMH水平升高且反映了卵巢大小。血清AMH水平可能是PCOS患者卵巢超声检查结果的替代指标，在PCOS诊断中，对于无需经阴道超声来评估卵巢情况可能有用。
