Chuvilin A N, Serebrennikova G A, Evstigneeva R P
Bioorg Khim. 1990 Sep;16(9):1157-76.
Properties of regulators of reversible haemoglobin oxygenation, especially of a natural regulator, 2,3-diphosphoglyceric acid (DPG), are reviewed. DPG provides effective deoxygenation of haemoglobin, helps to maintain its functional properties preventing its transformation into inactive derivatives. Correlation between organism metabolic requirements and haemoglobin oxygen affinity is established by erythrocyte DPG. Several functional analogues of DPG, their structure--activity relationship and possible medical application are discussed.
本文综述了血红蛋白可逆性氧合调节剂的特性，特别是天然调节剂2,3-二磷酸甘油酸（DPG）的特性。DPG可有效使血红蛋白脱氧，有助于维持其功能特性，防止其转化为无活性衍生物。红细胞DPG建立了机体代谢需求与血红蛋白氧亲和力之间的相关性。文中还讨论了DPG的几种功能类似物、它们的构效关系以及可能的医学应用。
