Böhning W, Ringe J D, Welzel D, Bode V
Karl-Hansen-Klinik für Atemwegserkrankungen und Allergie, Bad Lippspringe.
Arzneimittelforschung. 1990 Sep;40(9):1000-3.
In the present controlled study the effect of calcitonin nasal spray (CAS 47931-85-1; Lachs-Calcitonin Nasal spray Sandoz) on the bone mineral content was investigated in 36 patients in need of corticosteroid therapy suffering from chronic, obstructive lung diseases. The treatment consisted of 200 IU intranasal daily and lasted for one year. In the control group there was a statistically significant decline of bone mineral content of 5% or 4.3% concerning the lumbar vertebrae L1-L4 and the femur, whereas in the treated group there was only a statistically not significant decrease of 0.9% and 0.8%, respectively. These findings show that calcitonin nasal spray in a dose of 200 IU daily is quite useful for the prophylaxis of steroid-induced osteoporosis.
在本对照研究中，对36例患有慢性阻塞性肺疾病且需要接受皮质类固醇治疗的患者，研究了降钙素鼻喷雾剂（CAS 47931-85-1；山德士Lachs-降钙素鼻喷雾剂）对骨矿物质含量的影响。治疗方法为每日鼻内给予200 IU，持续一年。对照组中，L1-L4腰椎和股骨的骨矿物质含量出现了具有统计学意义的下降，分别为5%或4.3%，而治疗组中，仅分别出现了0.9%和0.8%的无统计学意义的下降。这些研究结果表明，每日剂量为200 IU的降钙素鼻喷雾剂对预防类固醇诱导的骨质疏松症非常有用。
