Ringe J D, Welzel D
Medical Clinic, Hamburg University, Federal Republic of Germany.
Eur J Clin Pharmacol. 1987;33(1):35-9. doi: 10.1007/BF00610377.
There is uncertainty about the best treatment for steroid-induced osteoporosis. Thirty-six patients with steroid-dependent, chronic obstructive lung disease and associated steroid osteoporosis have been studied, of whom 18 were treated with salmon calcitonin and the other 18 served as controls. Treatment lasted for 6 months and consisted of 100 I.U.s.c. every other day. In the controls there were significant decrements of 1.4% and 3.5%, respectively, in cortical and cortical and trabecular bone mineral content, whereas in subjects on calcitonin there were increments of 2.6% and 2.7%, respectively. Additional evidence of positive effect of calcitonin was derived from the reduced incidence of new fractures occurring during the observation period. A significant reduction in back pain was a further consequence of the hormone therapy.
对于类固醇诱导的骨质疏松症的最佳治疗方法尚无定论。对36例患有类固醇依赖型慢性阻塞性肺病及相关类固醇骨质疏松症的患者进行了研究，其中18例接受鲑鱼降钙素治疗，另外18例作为对照。治疗持续6个月，每隔一天皮下注射100国际单位。对照组的皮质骨和皮质骨及小梁骨矿物质含量分别显著下降了1.4%和3.5%，而接受降钙素治疗的患者则分别增加了2.6%和2.7%。降钙素积极作用的其他证据来自观察期内新骨折发生率的降低。激素治疗的另一个结果是背痛显著减轻。
