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对完整和垂体切除的胎羊在妊娠晚期及围产期肾上腺发育的定量组织学研究。

A quantitative histological study of adrenal development during late gestation and the perinatal period in intact and hypophysectomized fetal sheep.

作者信息

Nicolle A, Bosc M J

机构信息

INRA, Centre de Tours, Station de Physiologie de la Reproduction, Monnaie, France.

出版信息

Reprod Nutr Dev. 1990;30(6):653-62. doi: 10.1051/rnd:19900602.

DOI:10.1051/rnd:19900602
PMID:2080987
Abstract

Growth of the sheep adrenal was studied during late gestation and the perinatal period. Adrenals were recovered from 28 fetuses taken at D100 (D0: day of mating), D120, D132 and D144, and in 4 newborn animals 3 days after birth (equivalent to D151). Animals were of the Ile de France breed. Cortex (without capsule) and medulla volumes increased respectively by 7.2 and 2.4 between D100 and D151. The 2 parts had the same volume between D100 and D120; thereafter the cortex became predominant, representing 74% of the whole gland at D151. Hypertrophy and hyperplasia were shown after D132 in the cortex (zona fasciculata); they were observed later after D144 in the medulla (central zone). Fifteen fetuses hypophysectomized at D100 or D120 were recovered at D120 or D144. The lack of pituitary inhibited cortical growth (zona fasciculata) and suppressed hypertrophy and hyperplasia. The medulla continued to grow after hypophysectomy but to a lesser extent than in controls.

摘要

对绵羊妊娠后期及围产期肾上腺的生长情况进行了研究。从28只胎儿获取肾上腺,这些胎儿分别取自交配日(D0)后的第100天(D100)、第120天、第132天和第144天,以及4只新生动物出生后3天(相当于D151)。动物为法兰西岛品种。在D100至D151期间,皮质(无被膜)和髓质体积分别增加了7.2倍和2.4倍。在D100至D120期间,这两部分体积相同;此后皮质占主导地位,在D151时占整个腺体的74%。在D132之后,皮质(束状带)出现肥大和增生;在D144之后,髓质(中央区)较晚出现这些现象。15只在D100或D120接受垂体切除的胎儿在D120或D144时被回收。垂体缺失抑制了皮质生长(束状带),并抑制了肥大和增生。垂体切除后髓质继续生长,但程度低于对照组。

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