Coulter C L, Young I R, Browne C A, McMillen I C
Department of Physiology, Monash University, Clayton, Victoria, Australia.
Acta Endocrinol (Copenh). 1989 Mar;120(3):301-7. doi: 10.1530/acta.0.1200301.
We have investigated the effect of gestational age and fetal hypophysectomy on the growth and development of the adrenal gland of the fetal sheep. The area of the fetal sheep adrenal medulla increased significantly (P less than 0.05) from 3.21 +/- 0.42 mm2 at 90-107 days to 6.09 +/- 0.26 mm2 at 120-126 days of gestation and there was a further significant increase (P less than 0.05) in the newborn period to 9.48 +/- 0.85 mm2. The adrenomedullary area of the hypophysectomised fetal sheep (7.47 +/- 1.10 mm2) was not significantly different from that of the fetal sheep at 140-146 days of gestation or from that of the newborn lamb. The ratio of the area of the adrenal occupied by the cells which contained adrenaline (adrenaline zone) to the area of the adrenal occupied by the cells which contained noradrenaline (noradrenaline zone) was unchanged between 90 days of gestation and 12 days after birth. After hypophysectomy, the ratio of the adrenaline to noradrenaline zone was not significantly different from that in the adrenal medulla of the 140-146 days fetal sheep and the 10-12 days newborn lamb.
我们研究了胎龄和胎儿垂体切除对胎羊肾上腺生长发育的影响。胎羊肾上腺髓质面积在妊娠90 - 107天时为3.21±0.42平方毫米，至120 - 126天时显著增加（P<0.05），达到6.09±0.26平方毫米，在新生儿期进一步显著增加（P<0.05），至9.48±0.85平方毫米。垂体切除的胎羊肾上腺髓质面积（7.47±1.10平方毫米）与妊娠140 - 146天的胎羊或新生羔羊的肾上腺髓质面积无显著差异。妊娠90天至出生后12天，含肾上腺素细胞所占据的肾上腺面积（肾上腺素区）与含去甲肾上腺素细胞所占据的肾上腺面积（去甲肾上腺素区）之比无变化。垂体切除后，肾上腺素区与去甲肾上腺素区之比与妊娠140 - 146天的胎羊和出生10 - 12天的新生羔羊肾上腺髓质中的该比值无显著差异。
