Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
Mayo Clin Proc. 2010 Sep;85(9):785-90. doi: 10.4065/mcp.2010.0250.
To examine operative outcomes after acute pulmonary embolectomy (APE), a recently adopted, more aggressive surgical approach.
We retrospectively identified patients who underwent surgical APE from April 1, 2001, through March 31, 2009, and reviewed their clinical records for perioperative outcome. Operations were performed with normothermic cardiopulmonary bypass and a beating heart, absent a patent foramen ovale. For completeness, embolectomy was performed via separate incisions in the left and right pulmonary arteries (PAs) in 15 patients.
Of the 18 patients identified, the mean age was 60 years, and 13 patients (72%) were men. Thirteen patients (72%) had been hospitalized recently or had systemic disease. The preoperative diagnosis was established by echocardiography or computed tomography (or both). The median (range) follow-up time for all surviving patients was 16 months (2-74 months). Indications for APE included cardiogenic shock (n=12; 67%) and severe right ventricular dysfunction as shown by echocardiography (n=5; 28%). Seven patients (39%) had an embolus in transit. Seven patients (39%) experienced cardiopulmonary arrest before APE. Four early deaths (22%) occurred; all 4 of these patients had preoperative cardiopulmonary arrest, and 2 had APE via the main PA only, without branch PA incisions. Two late deaths (11%) occurred. Right ventricular function improved in all survivors.
The results of emergent APE are encouraging, particularly among patients without cardiopulmonary arrest. It should not be reserved for patients in extremis; rather, it should be considered for patients with right ventricular dysfunction that is an early sign of impending hemodynamic collapse.
探讨近期采用的更积极的手术方法——急性肺动脉血栓切除术(APE)的手术结果。
我们回顾性地确定了 2001 年 4 月 1 日至 2009 年 3 月 31 日期间接受手术 APE 的患者,并对其围手术期结果进行了回顾性分析。手术在常温体外循环和心脏不停跳下进行,没有卵圆孔未闭。为了完整性,15 例患者通过左、右肺动脉(PA)的单独切口进行血栓切除术。
在确定的 18 例患者中,平均年龄为 60 岁,13 例(72%)为男性。13 例(72%)患者最近住院或患有全身性疾病。术前诊断通过超声心动图或计算机断层扫描(或两者)确定。所有存活患者的中位(范围)随访时间为 16 个月(2-74 个月)。APE 的适应证包括心源性休克(n=12;67%)和超声心动图显示严重右心室功能障碍(n=5;28%)。7 例(39%)患者有栓子在移行中。7 例(39%)患者在 APE 前发生心肺骤停。4 例早期死亡(22%);这 4 例患者均有术前心肺骤停,2 例仅通过主 PA 进行 APE,而没有分支 PA 切口。2 例晚期死亡(11%)。所有幸存者的右心室功能均改善。
急诊 APE 的结果令人鼓舞,尤其是在没有心肺骤停的患者中。它不应仅保留给生命垂危的患者;相反,应考虑那些有右心室功能障碍的患者,因为这是即将发生血流动力学崩溃的早期征象。