长期定殖的白蛉唾液预先免疫未能保护免受大沙鼠利什曼原虫的实验性攻击以及野生捕获的白蛉唾液。
Lack of protection of pre-immunization with saliva of long-term colonized Phlebotomus papatasi against experimental challenge with Leishmania major and saliva of wild-caught P. papatasi.
机构信息
Laboratory of Vector Ecology, Laboratory of Epidemiology and Ecology of Parasites, and Laboratory of Immuno-Pathology, Vaccinology, and Molecular Genetics, Institut Pasteur de Tunis, Tunis, Tunisia.
出版信息
Am J Trop Med Hyg. 2010 Sep;83(3):512-4. doi: 10.4269/ajtmh.2010.09-0687.
Abstract
Immunity to saliva of Phlebotomus papatasi protects against Leishmania major infection as determined by co-inoculation of parasites with salivary gland homogenates (SGHs) of this vector. These results were obtained with long-term colonized female P. papatasi. We investigated the effect of pre-immunization with SGH of long-term colonized P. papatasi against L. major infection co-inoculated with SGH of wild-caught P. papatasi. Our results showed that pre-exposure to SGH of long-term, colonized P. papatasi do not confer protection against infection with L. major co-inoculated with SGH of wild-caught P. papatasi. These preliminary results strongly suggest that the effectiveness of a vector saliva-based vaccine derived from colonized sand fly populations may be affected by inconsistent immune response after natural exposure.
摘要
通过将寄生虫与这种媒介的唾液腺匀浆（SGH）共同接种来确定对 Phlebotomus papatasi 的唾液的免疫可以预防 Leishmania major 感染。这些结果是使用长期定殖的雌性 P. papatasi 获得的。我们研究了用长期定殖的 P. papatasi 的 SGH 进行预免疫对与野生捕获的 P. papatasi 的 SGH 共同接种的 L. major 感染的影响。我们的结果表明，预先暴露于长期定殖的 P. papatasi 的 SGH 并不能预防与野生捕获的 P. papatasi 的 SGH 共同接种的 L. major 感染。这些初步结果强烈表明，源自定殖沙蝇种群的基于媒介唾液的疫苗的有效性可能会受到自然暴露后不一致的免疫反应的影响。
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