Exp Dermatol. 2010 Dec;19(12):1103-5. doi: 10.1111/j.1600-0625.2010.01139.x. Epub 2010 Aug 31.
Vitamin D-binding protein (VDBP) single nucleotide polymorphisms (SNP) may affect skin carcinogenesis. The objective was to test the association between two functional VDBP SNPs and the susceptibility to (multiple) basal cell carcinomas (BCCs). Of the 7983 participants, 5790 (72.5%) and 5823 (72.9%) participants were genotyped for rs7041 and rs4588, respectively, and three haplotypes (Gc1s, Gc2 and Gc1f) were analysed. Two hundred and thirty-three persons developed a BCC of whom 122 (52.4%) developed multiple BCCs during a mean follow-up of 11.6 years. The VDBP genotype was not associated with (multiple) BCC development using Cox proportional hazards and Andersen-Gill analyses, respectively. Stratifying age groups demonstrated that in the youngest age-group, the A/T variant of rs7041 was associated with BCC development [adjusted hazard ratio (HR) = 1.88 (95%CI 1.10-3.20)], while homozygote Gc1s carriers had a significantly lower BCC risk [adjusted HR = 0.53 (95%CI 0.31-0.91)]. In conclusion, the VDBP polymorphisms were not associated with susceptibility to (multiple) BCCs, but age-gene interactions were observed.
维生素 D 结合蛋白 (VDBP) 单核苷酸多态性 (SNP) 可能影响皮肤癌发生。本研究旨在检验两个功能性 VDBP SNP 与（多发性）基底细胞癌 (BCC) 易感性之间的关联。在 7983 名参与者中，分别有 5790 名（72.5%）和 5823 名（72.9%）参与者接受了 rs7041 和 rs4588 的基因分型，并且分析了三个单倍型（Gc1s、Gc2 和 Gc1f）。233 人发生了 BCC，其中 122 人（52.4%）在平均 11.6 年的随访期间发生了多发性 BCC。使用 Cox 比例风险和 Andersen-Gill 分析，VDBP 基因型与（多发性）BCC 发展均无关联。分层年龄组表明，在最年轻的年龄组中，rs7041 的 A/T 变体与 BCC 发展相关[调整后的危险比 (HR) = 1.88 (95%CI 1.10-3.20)]，而纯合子 Gc1s 携带者的 BCC 风险显著降低[调整后的 HR = 0.53 (95%CI 0.31-0.91)]。总之，VDBP 多态性与（多发性）BCC 的易感性无关，但观察到了年龄与基因的相互作用。
