Department of Pharmaceutical Sciences, Faculty of Pharmacy, Mahasarakham University, Mahasarakham 44150, Thailand.
J Ethnopharmacol. 2010 Nov 11;132(2):491-6. doi: 10.1016/j.jep.2010.07.056. Epub 2010 Sep 8.
Pseuderanthemum palatiferum (Nees) Radlk (Acanthaceae) was first found in Northern Vietnam and expanded throughout the country including the Mekong Delta region. The leaves of this plant are recommended in folk medicine of Vietnam and Thailand for promoting and treating various diseases including hypertension, diarrhea, arthritis, hemorrhoids, stomachache, tumors, colitis, bleeding, wounds, constipation, flu, colon cancer, nephritis, and diabetes.
The hypoglycemic effect of an 80% ethanolic leaf extract from the leaves of Pseuderanthemum palatiferum (PPE) was investigated in normal and streptozotocin (STZ)-induced diabetic rats.
The PPE was administered daily and orally to the rats at the doses of 250, 500, and 1000 mg/kg body weight (b.w.) for 14 days. The levels of fasting plasma glucose (FPG), serum insulin, and biochemical data such as blood urea nitrogen (BUN), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and alkaline phosphatase (ALP) were evaluated. The hypoglycemic effect of PPE was compared to that of the known anti-diabetic drug glibenclamide (0.25 mg/kg b.w.).
FPG and serum insulin in normal rats were not significantly different from the control and test groups in all dosages. The treated diabetic rats which had received PPE and glibenclamide showed significantly (p<0.05) decreased FPG and increased serum insulin levels at the end of the experiment. The hypoglycemic effect of PPE at the dose of 250 mg/kg b.w. was significantly (p<0.05) more effective than that of glibenclamide. The serum insulin in PPE fed diabetic rats at the dose of 250 mg/kg b.w. was not different from those which had received glibenclamide, and this dose was significantly (p<0.05) more effective than PPE at the doses of 500 and 1000 mg/kg b.w. while PPE increased HDL and decreased TC, TG, LDL, BUN and ALP in the diabetic rats.
PPE has a beneficial effect in hyperglycemic rats and may prevent the complication of diabetes.
Palatiferum pseuderanthemum (Nees) Radlk（爵床科）最初在越南北部发现，随后在全国范围内（包括湄公河三角洲地区）扩展。这种植物的叶子在越南和泰国的民间医学中被推荐用于促进和治疗各种疾病，包括高血压、腹泻、关节炎、痔疮、胃痛、肿瘤、结肠炎、出血、伤口、便秘、流感、结肠癌、肾炎和糖尿病。
研究来自 Palatiferum pseuderanthemum（PPE）叶的 80%乙醇提取物对正常和链脲佐菌素（STZ）诱导的糖尿病大鼠的降血糖作用。
将 PPE 每天以 250、500 和 1000mg/kg 体重（b.w.）的剂量口服给予大鼠 14 天。评估空腹血糖（FPG）、血清胰岛素和生化数据，如血尿素氮（BUN）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和碱性磷酸酶（ALP）。将 PPE 的降血糖作用与已知的抗糖尿病药物格列本脲（0.25mg/kg b.w.）进行比较。
正常大鼠的 FPG 和血清胰岛素与对照组和试验组在所有剂量下均无显著差异。接受 PPE 和格列本脲治疗的糖尿病大鼠在实验结束时显示出 FPG 显著（p<0.05）降低和血清胰岛素水平显著（p<0.05）升高。PPE 250mg/kg b.w. 的降血糖作用明显（p<0.05）优于格列本脲。接受 PPE 250mg/kg b.w. 的糖尿病大鼠的血清胰岛素与接受格列本脲的大鼠没有差异，而该剂量比 500 和 1000mg/kg b.w. 的 PPE 更有效，同时 PPE 增加了糖尿病大鼠的 HDL，降低了 TC、TG、LDL、BUN 和 ALP。
PPE 对高血糖大鼠有有益的作用，并可能预防糖尿病的并发症。
