Department of Internal Medicine, University of Alabama at Birmingham, Huntsville, 35801, USA.
Anaerobe. 2010 Dec;16(6):626-8. doi: 10.1016/j.anaerobe.2010.08.005. Epub 2010 Sep 8.
Fusobacterium necrophorum can cause endemic pharyngitis and the Lemierre syndrome. Four previous case reports and one epidemiologic study have documented that some F. necrophorum pharyngitis patients develop bacteremia without developing the complete Lemierre syndrome. We report two more patients who have bacteremic F. necrophorum pharyngitis. We summarize the clinical presentation of these six patients. All received early diagnosis and excellent response to antibiotics. We speculate that prompt antibiotic treatment may have prevented the more serious Lemierre syndrome. Adolescents and young adults who present with significant pharyngotonsillitis and bacteremic symptoms should have blood cultures and receive antibiotic regimens that treat F. necrophorum. Recognition of such patients might prevent Lemierre syndrome.
败毒梭菌可引起地方性咽炎和勒米埃雷综合征。此前有 4 份病例报告和 1 项流行病学研究证明，一些败毒梭菌性咽炎患者会发生菌血症而不出现完整的勒米埃雷综合征。我们报告了另外两例患有败毒梭菌性咽峡炎的菌血症患者。我们总结了这 6 名患者的临床表现。所有患者均获得早期诊断和抗生素治疗的良好反应。我们推测，及时的抗生素治疗可能预防了更严重的勒米埃雷综合征。出现明显咽扁桃体炎和菌血症症状的青少年和年轻成年人应进行血培养，并接受治疗败毒梭菌的抗生素治疗方案。识别此类患者可能预防勒米埃雷综合征。
