Department of Pathology and Laboratory Medicine, Arkansas Children's Hospital, Little Rock, AR, USA.
Department of Pathology and Laboratory Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
J Infect Dis. 2024 Oct 23;230(Supplement_3):S182-S189. doi: 10.1093/infdis/jiae415.
Pharyngitis is an inflammatory condition of the pharynx and/or tonsils commonly seen in both children and adults. Viruses and bacteria represent the most common encountered etiologic agents-yeast/fungi and parasites are infrequently implicated. Some of these are predominantly observed in unique populations (eg, immunocompromised or unvaccinated individuals). This manuscript (part 2 of 3) summarizes the current state of laboratory and point-of-care diagnostic testing and highlights the expanding role of nucleic acid amplification in the expedited diagnosis and management of patients with acute pharyngitis. It discusses preanalytical, analytical, and postanalytical variables that impact the performance of culture, rapid antigen, and nucleic acid amplification testing. Finally, it sets the stage for part 3, which discusses the emerging role of biomarkers in the management of individuals with acute pharyngitis.
咽炎是一种常见于儿童和成人的咽部和/或扁桃体炎症。病毒和细菌是最常见的病因-酵母/真菌和寄生虫很少涉及。其中一些主要见于特定人群（例如，免疫功能低下或未接种疫苗的个体）。本手稿（共 3 部分中的第 2 部分）总结了目前实验室和即时诊断检测的状态，并强调了核酸扩增在加速诊断和管理急性咽炎患者方面的作用不断扩大。它讨论了影响培养、快速抗原和核酸扩增检测性能的分析前、分析中和分析后变量。最后，它为第 3 部分奠定了基础，该部分讨论了生物标志物在急性咽炎患者管理中的新兴作用。
